Positive Selection by the Pre-TCR Yields Mature CD8+ T Cells

Positive selection by the pre-TCR yields mature CD8+ T cells.

It has been of much interest whether there is functional redundancy between the constitutively signaling pre-Talpha/TCRbeta (pre-TCR) and ligated TCRalphabeta complexes, which independently operate the two distinct checkpoints during thymocyte development, i.e., the pre-TCR involved in beta-selection at the CD4(-)CD8(-) double-negative stage and the TCRalphabeta being crucial for positive/negat...

T Cells + Mature CD 8 Positive Selection by the Pre - TCR Yields

It has been of much interest whether there is functional redundancy between the constitutively signaling pre-T␣/TCR␤ (pre-TCR) and ligated TCR␣␤ complexes, which independently operate the two distinct checkpoints during thymocyte development, i.e., the pre-TCR involved in ␤-selection at the CD4 ؊ CD8 ؊ double-negative stage and the TCR␣␤ being crucial for positive/negative selection at the CD4 ...

T Cells + Mature CD 8 Positive Selection by the Pre - TCR Yields Aifantis , Harald von Boehmer and Toru Miyazaki

of April 18 , 2017 . This information is current as T Cells + Mature CD 8 Positive Selection by the Pre - TCR Yields

It has been of much interest whether there is functional redundancy between the constitutively signaling pre-T␣/TCR␤ (pre-TCR) and ligated TCR␣␤ complexes, which independently operate the two distinct checkpoints during thymocyte development, i.e., the pre-TCR involved in ␤-selection at the CD4 ؊ CD8 ؊ double-negative stage and the TCR␣␤ being crucial for positive/negative selection at the CD4 ...

A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo.

The T cell repertoire is shaped by the processes of positive and negative selection. During development, the TCR binds self peptide-MHC complexes in the thymus, and the kinetics of this interaction are thought to determine the thymocyte's fate. For development of CD8(+) T cells, the data supporting such a model have been obtained using fetal thymic organ culture. To confirm the fidelity of this...